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Histamine is broken down in the body via the enzyme DAO (diamine oxidase) and histamine N-methyltransferase. The newly developed THAK test determines the total histamine degradation capacity, regardless of which degradation pathway is relevant. By this, it has clear diagnostic advantages against measurement of DAO activity or DAO concentration. Current research shows that THAK is independent of dietary histamine content and delivers reliable results under a histamine elimination diet